Sildenafil boosts the impact of NO by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP from the corpus cavernosum. Sildenafil has no direct relaxant effect on isolated human corpus cavernosum.priapism, a painful erection that lasts more time than 4 several hours and may lead to permanent harm to your penis if

Low Blood Pressure (Hypotension). Sildenafil may possibly induce a delicate and non permanent drop in blood pressure. You may well be at a greater chance When you have specified health and fitness disorders or get blood pressure medicines.indications of a critical skin response which include blistering, peeling, a rash masking a significant space o